Dynamic in vivo 31P Magnetic Resonance Spectroscopy in Humans
MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague
Keywords: in vivo dynamic 31P MR spectroscopy, muscular energy metabolism, pH, mitochondrial capacity
The constructions of super high (3T) and ultra high field (7T) magnetic resonance (MR) imagers in the past decade have enabled many MR imaging and spectroscopy experiments with other nuclei than protons. The paper summarizes the basis of in vivo dynamic 31P MR spectroscopy for biomedical and clinical applications. The calculations of quantitative parameters of muscular metabolism, such as pH, mitochondrial capacity, ADP concentration, time constant of phosphocreatine recovery and others, are shown. The construction of ergometers for the whole body magnetic resonance systems is described. Examples of typical data processing and evaluation are demonstrated.
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