Synthesis of the PET Radiopharmaceutical [18F]Fluorocholine, Development of Analytical Methods and Optimization of Dimethylaminoethanol Content in the Final Product

Page: 604

F. Kužela, c, A. Novotnác, and J. Adamb,c

a FNSPE CTU, Praha, b RECAMO –; Masaryk Memorial Cancer Institute, Brno, c ÚJV Řež, a.s., Husinec-Řež

Keywords: positron emission tomography, radiopharmaceuticals, [18F]fluorocholine, analytical methods


[18F]fluorocholine is a substance of utmost importance for prostate carcinoma diagnostics by positron emission tomography (PET). The process of synthesis, development of quality control methods and optimization of performance to fulfill strict requirements of drug control authorities for commercial production of the substance are demonstrated.


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