Animal Lipoxygenases – Mechanism of Catalysis in Relation to Formation of Biologically Active Eicosanoids

Autoři

  • P. Hoffman Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
  • L. Bezáková Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
  • I. Holková Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
  • M. Pekárová Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
  • M. Obložinský Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic

Abstrakt

Lipoxygenases form a family of nonheme iron-containing enzymes involved in the lipid peroxidation processes. They participate, together with cyclooxy¬genases and cytochrome P-450, in the arachidonic acid metabolism, forming a group of cell signal molecules and secon¬dary messengers called eicosanoids. The lipoxygenase-catalyzed reactions are highly controlled processes media¬ted by steric shielding of substrate by bulky amino acid side chains in the reaction center. Equally important is the channeling of molecular oxygen and the anchoring of substrate in a substrate-binding cavity. From the viewpoint of development of new effective drugs, study of lipoxygena¬¬ses and bio¬logically active eicosanoids opens new horizons for affec-ting pathological processes.

Publikováno

15.08.2012

Jak citovat

Hoffman, P., Bezáková, L., Holková, I., Pekárová, M., & Obložinský, M. (2012). Animal Lipoxygenases – Mechanism of Catalysis in Relation to Formation of Biologically Active Eicosanoids. Chemické Listy, 106(7). Získáno z http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/890

Číslo

Sekce

Články

Nejaktuálnější články stejného autora (stejných autorů)