G-kvadruplexy v oblasti lidských telomer a jejich terapeutický potenciál

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  • P. Hubálková Ústav biochemie a mikrobiologie, Vysoká škola chemicko-technologická v Praze, Praha | Fyziologický ústav Akademie věd České republiky, v.v.i., Praha

Klíčová slova:

G-kvadruplex, telomery, nádorová onemocnění

Abstrakt

G-quadruplexes are types of secondary structures of nucleic acids, which are formed in guanine-rich regions. Their existence in vivo was confirmed in promoter regions of some genes and at the end of chromosomes in the telomeric regions. The specific structure of G-quadruplexes is a promising target in cancer treatment. There is a search for small ligands, which could stabilize a specific type of G-quadruplexes. Cancer cells are markedly different from normal cells in the telomeric region: the regions are profoundly shorter. Telomeric regions in cancer cells are prolonged by an enzyme telomerase, while this enzyme is inactive in almost all somatic cells. Stabilization of telomeric G-quadruplex by a specific small ligand induces disruption of a normal protective function of telomers leading to cell damage and its death. This approach could be successful in cancer treatment.

Stahování

Publikováno

15.12.2015

Jak citovat

Hubálková, P. (2015). G-kvadruplexy v oblasti lidských telomer a jejich terapeutický potenciál. Chemické Listy, 109(12), 918–922. Získáno z http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/273

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