Antioxidative Activity of Potential Antihypertensives with Dual Effect

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  • F. Šeršeň Institute of Chemistry, Slovak Academy of Sciences, Bratislava,
  • D. Loss Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic,
  • J. Csöllei Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic,
  • I. Popa Laboratory of Growth Regulators, Palacky University, Olomouc, Czech Republic,
  • J. Vančo Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic,
  • F. Gregáň Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Banská Bystrica, Slovak Republic

Abstrakt

The antioxidative properties of four 1-(2-benzofuran-2-yl-2-hydroxyethyl)-4-phenylpiperazines were studied by indirect spectrophotometric and direct ESR spin-trap methods. The radical scavenging activity of the tested compounds was determined. The compounds exhibit interesting structure-specific redox properties. Scavenging of DPPH radicals gave very poor results. The studied compounds did not affect the elimination of superoxide anion radicals; however, they caused stimulation of radical production. The hydroxyl radicals, however, were scavenged only by 2-fluoro¬phenyl derivatives, whereas the 4-fluorophenyl derivatives exhibited a slightly prooxidative effect. The capture of HO radicals by 2-fluorophenyl derivatives was, according to the results of NMR analyses, attributed to the interaction with non-protonated piperazine nitrogen atom, which is stabilized by the hydrogen bond between the hydroxy group and fluorine atom.

Publikováno

15.02.2007

Jak citovat

Šeršeň, F., Loss, D., Csöllei, J., Popa, I., Vančo, J., & Gregáň, F. (2007). Antioxidative Activity of Potential Antihypertensives with Dual Effect. Chemické Listy, 101(1). Získáno z http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1864

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