Increasing Bioavailability of Poorly Water-Soluble Drugs by Technological Methods Facilitating Drug Dissolution

Abstrakt

The paper brings an overview of most important methods for attaining the purpose, such as solubilization using tensides, cosolvents, chelates, cyclodextrins, pH modifiers, interactive powder mixtures forming solid dispersions and microgranulates. The review summarizes main advantages and drawbacks of the methods and gives some examples. Although, the most frequently used technology in pharmaceutical industry is currently drug micronization, the above methods offer a well established way of enhancing solubility of drugs in water.