Organokatalytické enantioselektivní oxidace sulfidů na sulfoxidy
Klíčová slova:asymetrické oxidace, sulfidy, sulfoxidy, organokatalýza, flaviny, flaviniové soli
Organocatalytic systems for enantioselective oxidations of sulfides to sulfoxides are reviewed. The most promising systems utilize hydrogen peroxide as final oxidant and chiral imines, chiral phosphoric acid derivatives, or chiral flavinium salts as catalysts which are able to provide oxidation of sulfides with enantioselectivities up to 80 % ee for aryl methyl sulfides and 91 % ee for tert-butyl methyl sulfide. In addition, enantioselective oxidations with iodylbenzene or iodylbenzoic acid in the presence of non-racemic substituted tartaric acid are mentioned.