Typy a příprava lipozomálních přípravků pro plicní podání
Klíčová slova:lipozomy, plicní aplikace, sprejové sušení, lyofilizace, suché práškové přípravky, protektanty
The use of liposomes as carriers for different types of drugs in formulations to be administered to the lungs brings a number of advantages, including the possibility of controlled release, prolongation of retention at the site of action or reduced systemic exposure. However, the main disadvantage of liposomal suspensions is their physical and chemical instability. Therefore, they are preferably converted to dry powders by several drying technologies. In doing so, it is necessary to include specific excipients in the formulation, in particular protectants (saccharides), protecting liposomes from changes during these processes.