Aromatic Ring Hydroxylating Dioxygenases – Structure - Function Relationships

Authors

  • J. Čapek Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • L. Musilová Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • T. Macek Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • O. Uhlík Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague

Keywords:

dioxygenases, aromatic ring, hydroxylation, active site

Abstract

Aromatic ring hydroxylating dioxygenases (ARHDs) catalyze the insertion of molecular oxygen into aromatic rings, forming arenedohromadydiols. ARHDs consist of a terminal oxygenase and an electron transport system. ARHDs are key enzymes in biodegradation of many aromatic pollutants, including both monoaromatic and polyaromatic hydrocarbons, or low-chlorinated biphenyls. In general, ARHDs show broad substrate specificity thus being able to transform various aromatic compounds. This study aims to summarize the current knowledge of ARHDs, including their structure, substrate specificity and the influence of amino acid residues on the enzymes.

Downloads

Published

2014-03-15

How to Cite

Čapek, J., Musilová, L., Macek, T., & Uhlík, O. (2014). Aromatic Ring Hydroxylating Dioxygenases – Structure - Function Relationships. Chemické Listy, 108(3), 182–190. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/532

Issue

Vol. 108 No. 3 (2014)

Section

Articles

Most read articles by the same author(s)

1 2 > >>