Synthesis of Protein Kinase Inhibitors

Authors

  • Francesca Scarpita Sicor S.r.l., Rho, Italy
  • Augusto Canavesi Sicor S.r.l., Rho, Italy
  • Alexandr Jegorov Teva Czech Industries s.r.o., Opava, Czech Republic

Keywords:

protein kinases, protein kinase inhibitors, sorafenib base, sorafenib tosylate

Abstract

Two procedures have been developed for the synthesis of sorafenib tosylate. The aim of the development was to minimize production of symmetric ureas in the course of synthesis, which create the major impurities of the preceeding processes and are difficult to remove. The major achievements were the purity of sorafenib thus obtained (> 99.8 %, HPLC) and possibility to scale up the syntheses.

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Published

2011-04-15

How to Cite

Scarpita, F., Canavesi, A., & Jegorov, A. (2011). Synthesis of Protein Kinase Inhibitors. Chemické Listy, 105(4), 278–281. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1157

Issue

Vol. 105 No. 4 (2011)

Section

Articles

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