Activation of G-Proteins by Metabotropic Glutamate Receptors and GABA B Receptors
Abstract
This review summarizes new findings on family 3 G-protein coupled receptors, also called metabotropic glutamate receptor (MGR) family, with respect to G-protein activation. In our studies we try to map the interface, which is crucial for G-protein activation. The interface includes intracellular loops of MGR, the loops 2 and 3 being especially important. On the GABAB receptor, the GB2 subunit contains enough molecular determinants for G-protein activation. Similarly to MGR, also here the corresponding intracellular loops are involved. On the G-protein side, the N-terminal preB1 region, C-terminal L9 loop and the extreme C-terminus are likely to contact the receptors in their active state.Downloads
Published
2004-02-15
How to Cite
Blahos, J., Havlickova, M., Zikova, A., Trojanova, J., Hruskova, B., Frankova, D., & Hlavackova, V. (2004). Activation of G-Proteins by Metabotropic Glutamate Receptors and GABA B Receptors. Chemické Listy, 98(1). Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2166
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