Advances in Studies of Insulin Interaction with Its Receptor

Authors

  • L. Žáková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague
  • J. Jiráček Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague

Keywords:

insulin, insulin synthesis, insulin analogs, insulin receptor, hormone, crystal structure, NMR structure, active conformation, insulin dimerization, diabetes mellitus

Abstract

Until recently, despite decades of intensive research, the exact mode of interaction of insulin with its membrane receptor remained elusive. However, recent advances achieved with insulin analogues and crystallographic studies with the insulin receptor provided a first insight into the interaction of insulin with its primary binding site on the insulin receptor. This review describes the story of insulin research at the above Institute.

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Published

2014-04-15

How to Cite

Žáková, L., & Jiráček, J. (2014). Advances in Studies of Insulin Interaction with Its Receptor. Chemické Listy, 108(4), 368–374. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/526

Issue

Vol. 108 No. 4 (2014)

Section

Articles