Stanovenie kyseliny listovej vo farmaceutických prípravkoch pomocou square-wave voltampérometrie na bórom dopovanej diamantovej elektróde
Klíčová slova:kyselina listová, bórom dopovaná diamantová elektróda, square-wave voltampérometria
Electrochemical behavior of folic acid (FA) was studied by cyclic voltammetry. An irreversible oxidation peak of FA was obtained at +0.85 V (Ag/AgCl, pH 5.0). The current dependence for square-wave voltammetry was linear at 1.0·10–7 – 17·10–4 M FA with a low detection limit of 3.0·10–8 M and good repeatability (RSD 2.8 %, n = 10). The method was used in analysis of tablets with recoveries 101.5 and 103.1 % and the determined values outside the confidence interval P = 95 %. The method is an alternative to widely used chromatographic methods.