Determination of Folic Acid in Pharmaceutical Preparations by Square-Wave Voltammetry Using a Boron-Doped Diamond Electrode

Authors

  • K. Cinková Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia
  • P. Šatkovská Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia
  • Ľ. Švorc Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

Keywords:

folic acid, boron-doped diamond electrode, square-wave voltammetry

Abstract

Electrochemical behavior of folic acid (FA) was studied by cyclic voltammetry. An irreversible oxidation peak of FA was obtained at +0.85 V (Ag/AgCl, pH 5.0). The current dependence for square-wave voltammetry was linear at 1.0·10–7 – 17·10–4 M FA with a low detection limit of 3.0·10–8 M and good repeatability (RSD 2.8 %, n = 10). The method was used in analysis of tablets with recoveries 101.5 and 103.1 % and the determined values outside the confidence interval P = 95 %. The method is an alternative to widely used chromatographic methods.

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Published

2015-10-15

How to Cite

Cinková, K., Šatkovská, P., & Švorc, Ľ. (2015). Determination of Folic Acid in Pharmaceutical Preparations by Square-Wave Voltammetry Using a Boron-Doped Diamond Electrode. Chemické Listy, 109(10), 788–793. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/303

Issue

Vol. 109 No. 10 (2015)

Section

Articles