RAS Proteins –– Key Regulators of Cell Cycle

Authors

  • H. Gbelcová Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic | Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
  • S. Rimpelová Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic
  • Z. Knejzlík Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic
  • V. Repiská Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
  • T. Ruml Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic
  • D. Böhmer Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia

Keywords:

RAS, activating mutation, farnesylation, cancer, RASopathy

Abstract

RAS proteins are small guanosine triphosphatases controlling the cell growth, differentiation, proliferation, survival, and death. They are encoded by ras proto-oncogenes, frequently mutated, in many cancer tissues and in the whole group of congenital defects. Understanding the structure, kinetics and signaling of RAS proteins allow the use of ras genes and RAS proteins as diagnostic bio­markers.

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Published

2015-05-15

How to Cite

Gbelcová, H., Rimpelová, S., Knejzlík, Z., Repiská, V., Ruml, T., & Böhmer, D. (2015). RAS Proteins –– Key Regulators of Cell Cycle. Chemické Listy, 109(5), 364–370. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/371

Issue

Vol. 109 No. 5 (2015)

Section

Articles