The Use of (Meth)acrylic Copolymers in the Production of Matrix Tablets with Controlled Drug Release

Authors

  • E. Mašková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • K. Kubová Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • D. Vetchý Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

Eudragit®, (meth)acrylic copolymers, matrix tablets, controlled release

Abstract

Eudragit® polymers are widely used acrylic pharmaceutical excipients. Over recent years, they have often been applied in matrix tablets with controlled drug release to improve the therapeutic activity and patient compliance. Eudragit® polymers can be used alone or combined with other poly(meth)acrylates or cellulose derivatives (hypromellose, ethylcellulose). Generally, Eudragit® matrices contain a soluble (lactose) or an indifferent filler (microcrystalline cellulose). Eudragit/s® is incorporated into matrix tablets to achieve a drug dissolution profile close to zero-order kinetics or the pH-independent release of a drug with pH-dependent solubility. Properties and dissolution behavior of Eudragit® matrices can be influenced by their thermal treatment.

Published

2015-01-15

How to Cite

Mašková, E., Kubová, K., & Vetchý, D. (2015). The Use of (Meth)acrylic Copolymers in the Production of Matrix Tablets with Controlled Drug Release. Chemické Listy, 109(1), 14–20. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/408

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