Lipophilic Formulations for Increasing Bioavailability of Poorly Water-Soluble Drugs

Authors

  • A. Franc Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • D. Vetchý Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • L. Smilková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • M. Rabišková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • B. Kratochvíl Department of Solid State Chemistry, Institute of Chemical Technology, Prague

Keywords:

highly soluble drugs, bioavailability enhancement, self-emulsifying systems, liposomes, lipid formulations, nanoparticles

Abstract

This review describes a new trend in the formulation of dosage forms containing poorly water-soluble drugs - lipophilic solutions, dispersions, liposomes and nanoparticles - dealing also with their composition and manufacture. The dispersions are further divided into non-emulsifying, self-emulsifying, self-microemulsifying and self-nanoemulsifying drug delivery systems. The cited systems are able to form micro- and nanoemulsions in contact with gastric juices. Formulations containing lipophilic nanoparticles as well as micro- and nanoemulsions are easily absorbed. A system classifying lipid formulations according to the drug composition is also described. The system enables the taxonomy of lipophilic drugs to be made; it also tries to describe their further metabolic ways in the organism.

Published

2012-01-15

How to Cite

Franc, A., Vetchý, D., Smilková, L., Rabišková, M., & Kratochvíl, B. (2012). Lipophilic Formulations for Increasing Bioavailability of Poorly Water-Soluble Drugs. Chemické Listy, 106(1), 3–9. Retrieved from http://ww.w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1006

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